医学教育

儿童神经发育与认知障碍重庆市重点实验室主任、教授、博士生导师。国家“优青”、重庆英才-创新领军人才、巴渝学者特聘教授、第四批重庆市学术技术带头人、重庆市首席专家工作室领衔专家、重庆市青年拔尖人才、重庆市青年科技奖和重庆市十佳科技青年奖获得者。担任中国医疗保健国际交流促进会认知障碍分会常委、中国神经科学学会应激神经生物学分会委员、中国神经科学学会离子通道与受体分会委员、中国卒中学会脑健康分会委员、中国生物物理学会衰老生物学分会委员、中国老年医学学会共病精准诊疗分会委员、重庆市青年科技领军人才协会理事、重庆市神经科学学会理事等。

课题组长期致力于认知障碍相关神经系统疾病发病机制及干预研究，如阿尔茨海默病、缺氧缺血性脑损伤、癫痫等。主持国家自然科学基金7项，重庆市自然科学基金重点项目、重庆市高校创新群体、重庆市中青年医学卓越团队等多项；在Neuron、J Clin Invest、PNAS、Cell Death Differ、Signal Transduct Target Ther、Aging Cell等发表SCI收录论文90余篇。研究成果先后获得重庆市自然科学奖二等奖（第一完成人），重庆市科技进步一等奖和教育部科技进步二等奖等。

成果奖励

1.2024：重庆市第四批学术技术带头人

2.2023：重庆市中青年医学卓越团队负责人

3.2022：重庆市首席专家工作室领衔专家

4.2020：重庆英才创新领军人才  

5.2020：巴渝学者特聘教授

6.2017：重庆市自然科学奖二等奖

7.2016：国家自然科学基金优秀青年科学基金

8.2015：首届重庆市十佳科技青年奖

9.2014：第八届重庆青年科技奖

10.2013：重庆市青年拔尖人才

11.2012：重庆市科技进步奖一等奖

12.2011：教育部高等学校科技进步奖二等奖

科研项目

1.2024.7-2027.6，YAP通过SCAP/SREBF1介导的脂质代谢促进新生鼠缺氧缺血性脑损伤的神经功能修复及其机制研究，重庆市自然科学基金创新发展联合基金（市教委）项目，50万（主持）

2.2024.1-2027.12，ELK1抑制SYVN1介导的PS1泛素化降解在阿尔茨海默病中的作用及机制研究，国家自然科学基金面上项目，50万（主持）

3.2023.7-2026.6，儿童脑损伤及其修复，重庆市中青年医学卓越团队，200万（团队负责人）

4.2021.1-2024.12，NLRP3炎症小体通过p97介导AMPA受体内吞在新生鼠缺氧缺血性脑损伤中的作用及其机制研究，国家自然科学基金面上项目，55万（主持）

5.2020.10-2023.10，抑制NLRP3炎症体/caspase-1/IL-1β通路调控的AMPA受体内吞在新生儿缺血缺氧性脑病修复中的作用及其机制研究，重庆市自然科学基金重点项目，80万（主持）

6.2019.7-2022.6，认知障碍相关疾病发病机制研究，重庆市高校创新研究群体，50万（群体负责人）

7.2018.1-2020.12，MKP-1抑制MAPK活化在阿尔兹海默病引起的神经退行性病变中的作用，国家自然科学基金重大研究计划培育项目，60万（主持）

8.2017.1-2019.12，阿尔茨海默症发病机理，国家自然科学基金优秀青年科学基金，130万（主持）

9.2016. 1-2019.12，抑制Nedd4-1介导的PTEN核转移在新生鼠缺氧缺血性脑损伤修复中的作用及相关机制研究，国家自然科学基金面上项目，57万（主持）

10.2013.1-2016.12，老年性痴呆症发病初期认知功能障碍的突触可塑性机制研究，国家自然科学基金面上项目，70万（主持）

11.2011.1-2012.12，新环境适应的海马突触可塑性机制，国家自然科学基金科学部主任基金，19万（主持）

论文情况

发表论文（#共同第一作者, *共同通讯作者）  

1.Long Z, Ge C, Zhao Y, Liu Y, Zeng Q, Tang Q*, Dong Z*, He G*. Enhanced autophagic clearance of amyloid-β via HDAC6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo. Neural Regen Res. 2025 Sep 1;20(9):2633-2644.

2.Tian N, Li J, Shi X, Xu M, Xiao Q, Tian Q, Chen M, Song W, Du Y*, Dong Z*. GALM Alleviates Aβ Pathology and Cognitive Deficit Through Increasing ADAM10 Maturation in a Mouse Model of Alzheimer's Disease. Neurosci Bull. 2025 Aug;41(8):1377-1389.

3.Xia L, Li J, Pazng Y, Dai C, Xu M, Du Y, Tian Q, Yi L, Wu B, Chen M, Qiu Y, Cheng C, Wang YT, Song W, Dong Z. Disruption of BAG3-mediated BACE1 stabilization alleviates neuropathology and memory deficits in a mouse model of Alzheimer's disease. Sci Adv. 2025 May 23;11(21):eadt7981.

4.Yi L, Li J, He Y, Wang J, Wang M, Guo S, Luo M, Wu B, Xu M, Tian Q, Fan Y, Chen M, Xu B, Xia L, Sonf W, He G*, Du Y*, Dong Z*. ELK1 inhibition alleviates amyloid pathology and memory decline by promoting the SYVN1-mediated ubiquitination and degradation of PS1 in Alzheimer’s disease. Exp Mol Med. 2025 May 1;57:1032 – 1046.

5.Wang M, Guo S, Yi L, Li Z, Shi X, Fan Y, Luo M, He Y, Song W, Du Y*, Dong Z*. KIF9 Ameliorates Neuropathology and Cognitive Dysfunction by Promoting Macroautophagy in a Mouse Model of Alzheimer's Disease. Aging Cell. 2025 May;24(5):e14490.

6.Li X, Chen M, Xu B, Fan Y, Dai C*, Dong Z*. VX-765 alleviates motor and cognitive impairments via inhibiting PANoptosis activation in the neonatal rats after hypoxic-ischemic brain damage. Pediatr Discov. 2024 May 1;3(1):e66.

7.He X#, Chen M#, Fan Y, Wu B, Dong Z. TFE3-Mediated Neuroprotection: Clearance of Aggregated α-Synuclein and Accumulated Mitochondria in the AAV-α-Synuclein Model of Parkinson's Disease. Genes Dis. 2025 Mar;12(2):101429.

8.Wu B#, Meng L#, Zhao Y, Li J, Tian Q, Ren C*, Dong Z*. Meningeal neutrophil immune signaling influences behavioral adaptation following threat. Neuron. 2025 Jan 22;113(2):260-276.e8

9.Tian Q, Li J, Wu B, Pang Y, He W, Xiao Q, Wang J, Yi L, Tian N, Shi X, Xia L, Tian X, Chen M, Fan Y, Xu B, Tao Y, Song W, Du Y*, Dong Z*. APP lysine 612 lactylation ameliorates amyloid pathology and memory decline in Alzheimer's disease. J Clin Invest. 2025 Jan 2;135(1):e184656.

10.Wang J, Dong Z*, Shi X*. Modified rat pup cerebrospinal fluid collection method. J Neurosci Methods. 2024 Oct 15;412:110302.

11.Xia L, Qiu Y, Li J, Xu M, Dong Z. The Potential Role of Artemisinins Against Neurodegenerative Diseases. Am J Chin Med. 2024;52(6):1641-1660.  

12.He W, Li D, Fan J, Yao Z, Cun Y, Dong Z. Maternal sleep deprivation disrupts glutamate metabolism in offspring rats. Zool Res. 2024 Nov 18;45(6):1221-1231.

13.Chen M#, He X#, Fan Y, Xia L, Dong Z. Sofalcone attenuates neurodegeneration in MPTP-induced mouse model of Parkinson's disease by inhibiting oxidative stress and neuroinflammation. Mol Biol Rep. 2024 Aug 14;51(1):908.

14.Yang S, Xu Y, Ahmad T, Deng Q, Gan Z, Yang Y, Yun H, Dong Z*, Tu S*. Mdivi-1 alleviates ferroptosis induced by hypoxia combined with propofol in HT22 cells by inhibiting excessive mitophagy. Mol Biol Rep. 2024 Jul 30;51(1):870.

15.Xia L, Li J, Pang Y, Xu M, Du Y, Chen M, Xu B, Qiu Y, Dong Z. Dihydroartemisinin promotes tau O-GlcNAcylation and improves cognitive function in hTau transgenic mice. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Jul 23;135:111105.  

16.Fan Y#, He X#, Chen M, Guo S, Dong Z. Pterostilbene alleviates MPTP-induced neurotoxicity by targeting neuroinflammation and oxidative stress. Biochem Biophys Res Commun. 2024 Jul 5;729:150358.

17.Wu B, Chen M, Meng L, Tian Q, Dong Z. Osteoclasts Link Dysregulated Peripheral Degradation Processes and Accelerated Progression in Alzheimer's Disease. J Alzheimers Dis. 2024;99(2):773-785.

18.Xiao Q, Wang J, Tian Q, Tian N, Tian Q, He X, Wang Y, Dong Z. Uric Acid Mitigates Cognitive Deficits via TFEB-Mediated Microglial Autophagy in Mice Models of Alzheimer’s Disease. Mol Neurobiol. 2024 Jun;61(6):3678-3696.

19.He W, Shi X*, Dong Z*. The roles of RACK1 in pathogenesis of Alzheimer's disease. J Biomed Res. 2024 Feb 27;38(2):137-148.  

20.Luo M, Pang Y, Li J, Yi L, Wu B, Tian Q, He Y, Wang M, Xia L, He G, Song W, Du Y*, Dong Z*. miR-429-3p mediates memory decline by targeting MKP-1 to reduce surface GluA1-containing AMPA receptors in a mouse model of Alzheimer’s disease. Acta Pharm Sin B. 2024 Feb;14(2):635-652.

21.Wang M#, Gu Y#, Li Q, Feng B, Lv X, Zhang H, Kong Q, Dong Z*, Tian X*, Zhang Y*. The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1. Genes Dis. 2024;11(3):100997.

22.Xu M, Li J, Xia L, Du Y, Wu B, Shi X, Tian N, Pang Y, Yi L, Chen M, Song W, Dong Z. PCSK6 exacerbates Alzheimer's disease pathogenesis by promoting MT5-MMP maturation. Exp Neurol. 2024 Apr;374:114688.

23.Xu M, Xia L, Li J, Du Y, Dong Z. 7,8-Dihydroxyflavone ameliorates cognitive impairment induced by repeated neonatal sevoflurane exposures in mice through increasing tau O-GlcNAcylation. Neurosci Lett. 2024 Jan 1;818:137559.

24.Yi L, Luo M, Wang M, Dong Z*, Du Y*. Fangchinoline alleviates cognitive impairments through enhancing autophagy and mitigating oxidative stress in Alzheimer's disease Models. Front Cell Dev Biol. 2023 Dec 11;11:1288506.

25.Tian Q, Li J, Wu B, Wang J, Xiao Q, Tian Na, Yi L, Luo M, Li Z, Pang Y, Shi X, Dong Z. Hypoxia-sensing VGLL4 promotes LDHA-driven lactate production to ameliorate neuronal dysfunction in a cellular model relevant to Alzheimer's disease. FASEB J. 2023 Dec;37(12):e23290.

26.Chen Y, Li X, Xiong Q, Du Y, Luo M, Yi L, Pang Y, Shi X, Wang YT, Dong Z. Inhibiting NLRP3 inflammasome signaling pathway promotes neurological recovery following hypoxic-ischemic brain damage by increasing p97-mediated surface GluA1-containing AMPA receptors. J Transl Med. 2023 Aug 24;21(1):567.

27.Li J, Pang Y, Du Y, Xia L, Chen M, Fan Y, Dong Z. Lack of interferon regulatory factor 3 leads to anxiety/depression-like behaviors through disrupting the balance of neuronal excitation and inhibition in mice. Genes Dis. 2023;10:1062-1074.

28.Du Y#*, Li J#, Wang  M, Tian Q, Pang Y, Wen Y, Wu D, Wang YT, Dong Z*. Genetic inhibition of glutamate allosteric potentiation of GABAARs in mice results in hyperexcitability, leading to neurobehavioral abnormalities. MedComm. 2023;4:e235.

29.Cheng K#, Wang Y#, He Y#, Tian Y#, Li J#, Chen C, Xu X, Wu Z, Yu H, Chen X, Wu Y, Song W*, Dong Z*, Xu H*, Xie P*. Upregulation of carbonic anhydrase 1 beneficial for depressive disorder. Acta Neuropathol Commun. 2023 Apr 3;11(1):59.

30.He Y#, Li J#, Yi L, Li X, Luo M, Pang Y, Wang M, Li Z, Xu M, Dong Z*, Du Y*. Octadecaneuropeptide Ameliorates Cognitive Impairments Through Inhibiting Oxidative Stress in Alzheimer's Disease Models. J Alzheimers Dis. 2023;92(4):1413-1426.  

31.Su Y, Yang X, Yang L, Liu X, She Z, Zhang Y, Dong Z. Thyroid Hormones Regulate Reelin Expression in Neuropsychiatric Disorders. Can J Physiol Pharmacol. 2022 Sep 27. Can J Physiol Pharmacol. 2022 Nov 1;100(11):1045-1054.  

32.Wen Y#, Dong Z#, Liu J, Axerio-Cilies P, Du Y, Li J, Chen L, Zhang L, Liu L, Lu J, Zhou N, Chuan Wu D*, Wang YT*. Glutamate and GABAA receptor crosstalk mediates homeostatic regulation of neuronal excitation in the mammalian brain. Signal Transduct Target Ther. 2022 Oct 3;7(1):340.  

33.Wang Y, Xia L, Wu B, Dong Z*, Du Y*. Octadecaneuropeptide Alleviates Motor and Cognitive Impairments in Neonatal Rats Following Hypoxic-Ischemic Brain Damage. J Mol Neurosci. 2022 Aug;72(8):1636-1645.

34.Xiong Q, Li X, Xia L, Yao Z, Shi X*, Dong Z*. Dihydroartemisinin attenuates hypoxic-ischemic brain damage in neonatal rats by inhibiting oxidative stress. Mol Brain. 2022 Apr 28;15(1):36.

35.Yao Z, Li X, Zuo L, Xiong Q, He W, Li D, Dong Z. Maternal sleep deprivation induces gut microbial dysbiosis and neuroinflammation in offspring rats. Zool Res. 2022 May 18;43(3):380-390.  

36.Xia L#, Pang Y#, Li J, Wu B, Du Y, Chen Y, Luo M, Wang Y, Dong Z. Dihydroartemisinin induces O-GlcNAcylation and improves cognitive function in a mouse model of tauopathy. J Alzheimers Dis. 2021;84(1):239-248.

37.Zuo L, Dai C, Yi L, Dong Z. 7,8-dihydroxyflavone ameliorates motor deficits via regulating autophagy in MPTP-induced mouse model of Parkinson’s disease. Cell Death Discov. 2021 Sep 20;7(1):254.

38.Dai C, Wu B, Chen Y, Li X, Bai Y, Du Y, Pang Y, Wang YT, Dong Z. Aagab acts as a novel regulator of NEDD4-1-mediated Pten nuclear translocation to promote neurological recovery following hypoxic-ischemic brain damage. Cell Death Differ. 2021 Aug;28(8):2367-2384.

39.Jin JW#, Fan X#, Del Cid-Pellitero E#, Liu XX, Zhou L, Dai C, Gibbs E, He W, Li H, Wu X, Hill A, Leavitt BR, Cashman N, Liu L, Lu J, Durcan TM, Dong Z*, Fon EA*, Wang YT*. Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models. Commun Biol. 2021 Feb 19;4(1):232.

40.He W, Tu M, Du Y, Li J, Pang Y, Dong Z. Nicotine Promotes AβPP Nonamyloidogenic Processing via RACK1-Dependent Activation of PKC in SH-SY5Y-AβPP695 Cells. J Alzheimers Dis. 2020;75(2):451-460.

41.Zhang Y, Dong Z*, Song W*. NLRP3 inflammasome as a novel therapeutic target for Alzheimer’s disease. Signal Transduct Target Ther. 2020 April 1;5:37.

42.Zhang L*, Dong Z*, Zhang J. Immunomodulatory role of mesenchymal stem cells in Alzheimer's disease. Life Sci. 2020 Apr 1;246:117405.

43.Du Y#, Fu M#, Huang Z, Tian X, Li J, Pang Y, Song W, Wang YT, Dong Z. TRPV1 activation alleviates cognitive and synaptic plasticity impairments through inhibiting AMPAR endocytosis in APP23/PS45 mouse model of Alzheimer’s disease. Aging Cell. 2020 Mar;19(3):e13113.

44.Du Y, Du Y, Zhang Y, Huang Z, Fu M, Li J, Pang Y, Lei P, Wang TY, Song W*, He G*, Dong Z*. MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models. Signal Transduct Target Ther. 2019 Dec 6;4:58.  

45.Xu K#, He Y#, Chen X#, Tian Y#, Cheng K#, Zhang L#, Wang Y, Yang D, Wang H, Wu Z, Li Y, Lan T, Dong Z*, Xie P*. Validation of the Targeted Metabolomic Pathway in the Hippocampus and Comparative Analysis with the Prefrontal Cortex of Social Defeat Model Mice. J Neurochem. 2019 Jun;149(6):799-810.

46.Zhou L, Chen L, Li X, Li T, Dong Z*, Wang YT*. Food allergy induces alteration in brain inflammatory status and cognitive impairments. Behav Brain Res. 2019 May 17;364:374-382.

47.Du Y#, Fu M#, Wang YT, Dong Z. Neuroprotective effects of ginsenoside Rf on Aβ-induced neurotoxicity in vitro and in vivo. J Alzheimers Dis. 2018;64(1):309-322.

48.Tan T#, Wang W#, Xu H, Huang Z, Wang YT, Dong Z. Low-Frequency rTMS Ameliorates Autistic-Like Behaviors in Rats Induced by Neonatal Isolation Through Regulating the Synaptic GABA Transmission. Front Cell Neurosci. 2018 Feb 28;12:46.

49.Yu Y, Huang Z, Dai C, Du Y, Han H, Wang YT*, Dong Z*. Facilitated AMPAR endocytosis causally contributes to the maternal sleep deprivation-induced impairments of synaptic plasticity and cognition in the offspring rats. Neuropharmacology. 2018 Jan 29;133:155-162.

50.Wang W#, Tan T#, Yu Y#, Huang Z, Du Y, Han H, Dong Z. Inhibition of AMPAR endocytosis alleviates pentobarbital-induced spatial memory deficits and synaptic depression . Behav Brain Res. 2018 Feb 26;339:66-72.

51.Guo H#, Huang Z#, Wang W#, Zhang S#, Li J#, Cheng K#, Xu K, He Y, Gui S, Li P, Wang H, Dong Z*, Xie P*. iTRAQ-Based Proteomics Suggests Ephb6 as a Potential Regulator of the ERK Pathway in the Prefrontal Cortex of Chronic Social Defeat Stress Model Mice. Proteomics Clin Appl. 2017 Dec;11(11-12).

52.Dai C, Liu Y, Dong Z. Tanshinone I alleviates motor and cognitive impairments via suppressing oxidative stress in the neonatal rats after hypoxic-ischemic brain damage. Mol Brain. 2017 Nov 14;10(1):52.

53.Huang Z#, Tan T#, Du Y, Chen L, Fu M, Yu Y, Zhang L, Song W, Dong Z. Low-Frequency Repetitive Transcranial Magnetic Stimulation Ameliorates Cognitive Function and Synaptic Plasticity in APP23/PS45 Mouse Model of Alzheimer’s Disease. Front Aging Neurosci. 2017 Sep 12;9:292.

54.Chen L, Huang Z, Du Y, Fu M, Han H, Wang Y, Dong Z. Capsaicin Attenuates Amyloid-β-Induced Synapse Loss and Cognitive Impairments in Mice. J Alzheimers Dis. 2017;59(2):683-694.

55.Li Y#, Chen L#, Du Y#, Huang D, Han H, Dong Z. Fluoxetine Ameliorates Atopic Dermatitis-Like Skin Lesions in BALB/c Mice through Reducing Psychological Stress and Inflammatory Response. Front Pharmacol. 2016 Sep 13;7:318.

56.Li X, Dai C, Chen L, Zhou W, Han H, Dong Z. 7,8-dihydroxyflavone ameliorates motor deficits via suppressing a-synuclein expression and oxidative stress in the MPTP-induced mouse model of parkinson’s disease. CNS Neurosci Ther. 2016 Jul;22(7):617-24.

57.Chen L, Wang W, Tan T, Han H, Dong Z. GABAA receptors in the central nucleus of amygdala are involved in pain- and itch-related responses. J Pain. 2016 Feb;17(2):181-9.

58.Zhou L#, Bai Y#, Li Y, Liu X, Tan T, Meng S, He W, Wu X*, Dong Z*. Overexpression of MCPH1 inhibits uncontrolled cell growth by promoting cell apoptosis and arresting the cell cycle in S and G2/M phase in lung cancer cells. Oncol Lett. 2016 Jan;11(1):365-372.  

59.Dong Z*, Han H, Li H, Bai Y, Wang W, Tu M, Peng Y, Zhou L, He W, Wu X, Tan T, Liu M, Wu X, Zhou W, Jin W, Zhang S, Sacktor TC, Li T*, Song W*, Wang YT*. Long-term potentiation decay and memory loss are mediated by AMPAR endocytosis. J Clin Invest. 2015;125(1):234–247.  

60.Han H, Dai C, Dong Z. Single fluoxetine treatment before but not after stress prevents stress-induced hippocampal long-term depression and spatial memory retrieval impairment in rats. Sci Rep. 2015 Jul 28;5:12667.  

61.Han H, Peng Y, Dong Z. D-serine rescues the deficits of hippocampal long-term potentiation and learning and memory induced by sodium fluoroacetate. Pharmacol Biochem Behav. 2015 Jun;133 (2015) 51–56.  

62.Wu X, Bai Y, Tan T, Li H, Xia S, Chang X, Zhou Z, Zhou W, Li T, Wang YT, Dong Z. Lithium ameliorates autistic-like behaviors induced by neonatal isolation in rats. Front Behav Neurosci. 2014 Jun 26;8:234.  

63.Bai Y, Zhou L, Wu X, Dong Z. D-Serine enhances fear extinction by increasing GluA2-containing AMPA receptor endocytosis. Behav Brain Res. 2014 May 23;270C:223-227.

64.Dong Z*, Bai Y, Wu X, Li H, Gong B, Howland JG, Huang Y, He W, Li T, Wang YT*. Hippocampal long-term depression mediates spatial reversal learning in the Morris water maze. Neuropharmacology. 2013 Jan;64:65-73.

65.Dong Z*, Gong B, Li H, Bai Y, Wu X, Huang Y, He W, Li T, Wang YT*. Mechanisms of Hippocampal Long-Term Depression Are Required for Memory Enhancement by Novelty Exploration. J Neurosci. 2012 Aug 29; 32(35):11980-90.  

66.Li H, Wu X, Bai Y, Huang Y, He W, Dong Z. Unilateral lesion of dorsal hippocampus in adult rats impairs contralateral long-term potentiation in vivo and spatial memory in the early postoperative phase. Behav Brain Res. 2012 May 1;230(2):428-32.  

67.Ge Y#, Dong Z#, Bagot R, Howland J, Phillips A, Wong TP*, Wang YT*. Hippocampal long-term depression is required for the consolidation of spatial memory. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16697-702.

68.Dong Z, Han H, Cao J, Xu L. Opioid withdrawal for 4 days prevents synaptic depression induced by low dose of morphine or naloxone in rat hippocampal CA1 area in vivo. Hippocampus. 2010 Feb;20(2):335-43.

69.Dong Z#, Han H#, Cao J, Zhang X, Xu L. Coincident activity of converging pathways enables simultaneous long-term potentiation and long-term depression in hippocampal CA1 network in vivo. PLoS ONE. 2008 Aug 6;3(8):e2848.

70.Dong Z#, Zhong W#, Tian M, Han H, Mao R, Cao J, Sui N, Xu T, Luo J, Xu L. Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio. Brain Res. 2008 May 1;1207:164-73.

71.Dong Z, Cao J, Xu L. Opiate withdrawal modifies synaptic plasticity in subicular-nucleus accumbens pathway in vivo. Neuroscience. 2007 Feb 9;144(3):845-54.

72.Dong Z#, Zhong W#, Tian M, Han H, Cao J, Xu T, Luo J, Xu L. Stress evoked by opiate withdrawal facilitates hippocampal LTP in vivo. Hippocampus. 2006;16(12):1017-25.  

73.Dong Z, Han H, Wang M, Xu L, Hao W, Cao J. Morphine conditioned place preference depends on glucocorticoid receptors in both hippocampus and nucleus accumbens. Hippocampus. 2006;16(10):809-13.  

74.Dong Z, Mao R, Han H, Cao J, Xu L. Morphine withdrawal modifies antinociceptive effects of acute morphine in rats. Biochem Biophys Res Commun. 2006 Jul 28;346(2):578-82.

75.Zhong W#, Dong Z#, Tian M, Cao J, Xu T, Xu L, Luo J. Opiate withdrawal induces dynamic expressions of AMPA receptors and its regulatory molecule CaMKIIalpha in hippocampal synapses. Life Sci. 2006 Jul 24;79(9):861-9.  

76.Zhong WX#, Dong Z#, Tian M, Cao J, Xu L, Luo JH. N-methyl-d-aspartate receptor-dependent long-term potentiation in CA1 region affects synaptic expression of glutamate creceptor subunits and associated proteins in the whole hippocampus. Neuroscience. 2006 Sep 1;141(3):1399-413.